Analysis performed on 2024-09-30 10:19:47
| Initial | Filtered Out | Final | Blast | |
|---|---|---|---|---|
| Bacteria | 45892 | 712 | 45180 | 26362 |
| Archaea | 3414 | 132 | 3282 | 1408 |
| Vertebrata | 1592 | 72 | 1520 | 529 |
| Mammals | 595 | 27 | 568 | 138 |
| Protein Length | Pathogenic Variants | Benign/Unknown Variants |
|---|---|---|
| 968 | 89 | 985 |
| Domains | |
|---|---|
| Current Study | No Domains Found |
| Guo et al (2010) | No Domains Listed |
| Ancient Domains | Modern Domains | All | Ratio | |
|---|---|---|---|---|
| Number of Residues | 968 | 0 | 968 | Undefined |
| Number of Variants | 1074 | 0 | 1074 | Undefined |
| Number of Pathogenic Variants | 89 | 0 | 89 | Undefined |
| Number of Benign/Unknown Variants | 985 | 0 | 985 | Undefined |
| Fisher exact test | Undefined |
The Fisher exact test was calculated using a contingency table with the number of pathogenic and benign/unknown variants in ancient and modern domains. The bottom left values.
| Ancient Domains | Modern Domains | All | Ratio | |
|---|---|---|---|---|
| Number of Residues | 968 | 0 | 968 | Undefined |
| Number of Variants | 1074 | 0 | 1074 | Undefined |
| Number of Pathogenic Variants | 89 | 0 | 89 | Undefined |
| Number of Benign/Unknown Variants | 985 | 0 | 985 | Undefined |
| Fisher exact test | Undefined |
The Fisher exact test was calculated using a contingency table with the number of pathogenic and benign/unknown variants in ancient and modern domains. The bottom left values.
| # of sites Ancient | # sites Modern | Mean Ancient (SD) | Mean Modern (SD) | Median Ancient | Median Modern | Mann-Whitney U | p-value | |
|---|---|---|---|---|---|---|---|---|
| Current Study | 968 | 0 | 0.77 (0.01) | nan (nan) | 7.615e-01 | NaN | Undefined | Undefined |
| Guo et al (2010) | 968 | 0 | 0.77 (0.01) | nan (nan) | 7.615e-01 | NaN | Undefined | Undefined |
The Mann-Whitney U test was calculated using the conservation scores of the amino acids in ancient and modern domains. The p-value is for the null hypothesis that the conservation scores in ancient domains are greater than in modern domains.